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Tag Archive - DNA Sequencing

NGS-Different-Sanger-Sequencing

How is NGS Different from Sanger Sequencing?

Introduction Sequencing DNA involves biochemical processes to ascertain the order (sequence) of nucleotides of DNA strands. Maxam-Gilbert and Sanger methods were developed over 40 years ago, but the Sanger method soon dominated the DNA sequencing arena. With this method, DNA is repeatedly copied resulting in DNA fragments of varying lengths. The ends of each fragment are labeled with a chain terminator, and this allows the determination of the DNA sequence.…

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Chromatin Immunoprecipitation-sequencing-macrogen

Chromatin Immunoprecipitation-sequencing (ChIP-seq)

Chromatin Immunoprecipitation assays have the ability to capture an image of specific protein to DNA interactions that are occurring in a system and process these interactions using quantitative polymerase chain reaction (qPCR), ChIP-chip, or next generation sequencing (NGS). When paired with next generation sequencing specifically, ChIP-seq is a powerful way to identify genome-wide DNA binding sites for transcription factors and other proteins. When performing ChIP-seq, chromatin is separated from cells…

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precisionfda logo

Macrogen Corp Announced as precision FDA Participating Provider

Macrogen Corp., one of the leading providers of next-generation sequencing services, has been announced as a participating provider in precisionFDA. The precisionFDA web platform is part of President Obama’s vision with his Precision Medical Initiative announced last year. The administration’s goal is to move away from a “one-size-fits-all” approach to medicine and move towards a personalized medicine approach that takes into account differences in people’s genes, environments, and lifestyles. The…

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DNA conference

The Top Five Genome Conferences In The World

The emergence and growth of whole genome sequencing technologies, and the resulting immense database generated, requires that scientists and medical professionals learn more about the powerful tools available to them. These tools give scientists the ability to interpret and apply the information and are becoming increasingly available. Genomic technologies have bolstered the power of personalized medicine and are facilitating drug discovery. A plethora of genomic conferences that focus on a…

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high-throughput dna sequencing

Managing High-Throughput DNA Sequencing Data

Introduction The newest sequencing technologies are providing new insights into disease etiology, individual susceptibilities, keys to drug discovery, and more. However, there are many questions and challenges regarding how to understand the meaning and applicability of the newfound wealth of data. As new data is generated at record rates, scientists are working diligently on the development of methods to archive the massive sequencing information and create bioinformatics tools to analyze…

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DRAGEN Processor

Macrogen Deploys Advanced Data Processors for Faster Analysis of Large-Scale Genomic and Sequencing Data

Macrogen recently partnered with Edico Genome to reinforce its Bio-IT infrastructure with new DRAGEN processors. By deploying several DRAGEN Bio-IT Processors, which are designed and manufactured by Edico Genome, Macrogen will be able to provide faster processing and analysis of high-throughput NGS data. Accurate DNA sequencing and genomic analysis is reliant on advanced technology. To this end, clinicians and researchers use powerful processors and collection instruments to capture and analyze…

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Dna Strands

How the Genome Asia 100K Initiative is Impacting Disease Research

The Genome Asia 100K Initiative announcement made big waves earlier this year as it is the first significant pan-Asian endeavor with the goal of creating a comprehensive genomic database. The initiative is similar to the 100K Genome Project in the United Kingdom and the US Precision Medicine Initiative. The Genome Asia 100K initiative is led by a consortium of companies, academics, and other major stakeholders in the field of genetics.…

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drug resistant bacteria

Discovering Drug Resistance Using DNA Sequencing

What is Drug Resistance? The World Health Organization (WHO) defines drug resistance (also called antimicrobial resistance) as the change that occurs in microorganisms that renders medications ineffective. There are other types of drug resistance, such as cancer cell resistance to chemotherapeutic agents. This discussion, however, will focus on antimicrobial drug resistance. As antimicrobial drugs become less effective, it is more difficult to combat infections that were previously manageable. Developing means…

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Tablet being used for personalized medicine

DNA Sequencing: The Backbone of Personalized Medicine

Concept of Personalized Medical Care As a society, we have been accustomed to the concept of a “one-size-fits-all” approach to healthcare. However, this has not been ideal for many people and limits the success of medical management. There are instances where there is some level of tailoring to the individual, but not to the extent needed to address the numerous nuisances that can affect the optimal results of a person’s…

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3d render of dna structure for transposon sequencing

How Transposons are Changing the Sequencing Industry

Introduction Mobile DNA segments that can change position, transpose, are transposons (or transposable elements). These “jumping genes” discovered by Barbara McClintock 70 years ago exist in species of all kingdoms, from bacteria to humans. Transposons make up large portions of a species’ genome and have key biological functions. In humans, transposons make up nearly 50% of the genome; however, only a very small portion of the transposons are still actually…

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