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HLA-Pharmacogenetics-Macrogen-Labs

HLA and Pharmacogenetics

Introduction For years, the unpredictability of drug reactions has served as an underlying uncertainty in the safety of medications. This is because many of these reactions are specific to certain individuals and populations and under specific circumstances with an unknown basis. Adverse drug reactions can be very medically devastating, leading to severe consequences including death. The capacity to find a means to predict the risk of adverse reactions for patients…

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Role of Epigenetic Changes in the Etiology of Human Diseases

Introduction The field of epigenetics is ever-growing and considered to be a relatively new branch of genetic research. However, the concept dates back to the 1940s when it was understood as a mechanism that involved gene and gene-product interactions responsible for phenotypic expression1. Epigenetics is now understood as stable, heritable changes in gene expression that are not associated with changes in the actual DNA sequence. That means that the phenotype…

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Using Whole Genome Sequencing in Patients with Neuromyelitis Optica

In the April 2014 Edition of Neurology, Benjamin Greenberg, Douglas Kerr, Tim Harris, Aaron Day-Williams and John Carulliwrote about a study that was conducted to deduce the inheritance pattern of those who suffered from Neuromyelitis Optica. Neuromyelitis Optica is an uncommon autoimmune disorder that can affect the nervous system, optic nerves, and the spinal cord. Those who have this disease commonly experience pain in the eyes and vision loss. Along…

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