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race-and-predisposition

Race and Predisposition to Disease

Introduction Interdisciplinary efforts over several decades have provided intriguing information regarding the factors that contribute to racial differences in health status and outcomes. Even with this information on hand, challenges remain regarding improved characterization of these various biological and environmental factors. Advances in genomic studies have provided some of the valuable tools and data needed to move forward in the direction of defining the biologic factors underlying racial differences in…

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NGS-life-expectancy

Next Generation Sequencing Could Dramatically Impact Life Expectancy

Introduction A Centers for Disease Control website provides a definition for life expectancy as “the average number of years that a hypothetical group of infants would live at each attained age if the group was subject, throughout its lifetime, to the age-specific death rates prevailing for the actual population in a given year” (1). It is essentially the time a person or other organism is expected to live based on…

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Chromatin Immunoprecipitation-sequencing-macrogen

Chromatin Immunoprecipitation-sequencing (ChIP-seq)

Chromatin Immunoprecipitation assays have the ability to capture an image of specific protein to DNA interactions that are occurring in a system and process these interactions using quantitative polymerase chain reaction (qPCR), ChIP-chip, or next generation sequencing (NGS). When paired with next generation sequencing specifically, ChIP-seq is a powerful way to identify genome-wide DNA binding sites for transcription factors and other proteins. When performing ChIP-seq, chromatin is separated from cells…

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recombinant-vaccines-macrogen

Sequencing Data to Develop Recombinant Vaccines

Introduction Eradication and prevention of infectious diseases are achieved most often via vaccination. The common or traditional vaccines are made using the actual pathogen material, such as modified live or killed (inactivated) viruses. The use of these types of vaccines is sometimes associated with serious side effects. For some infectious agents, it is often difficult to develop vaccines using this approach, and there are limitations on the effectiveness of these…

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Macrogen Microbiome

Advances in Microbiome Diagnostics

Introduction The organisms that are a part of our normal biology are essential for our survival and well-being. The genetic material of these organisms collectively makes up the human microbiome. However, there are many scientists that use the term microbiome interchangeably with microbiota (the actual normal microorganism in a particular environment, such as the human body). For the purposes of this article, microbiome will be reserved for indicating the total…

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Cloud-based Technology Concept

The Promise and Security Risks of using Cloud-Based Informatics Solutions for Human Genomic Data Analysis

Introduction The ability for medical and research scientists around the globe to share data has enhanced the progress of medical discovery and healthcare delivery. Instant access to information via cloud-based technology by researchers and healthcare providers allows more time spent acting on and processing data. However, large bodies of data (a.k.a big data) generated through new technologies such as next-generation sequencing (NGS) need special data-storage considerations. Storage of a vast…

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DNA conference

The Top Five Genome Conferences In The World

The emergence and growth of whole genome sequencing technologies, and the resulting immense database generated, requires that scientists and medical professionals learn more about the powerful tools available to them. These tools give scientists the ability to interpret and apply the information and are becoming increasingly available. Genomic technologies have bolstered the power of personalized medicine and are facilitating drug discovery. A plethora of genomic conferences that focus on a…

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Macrogen Provides Patient-Specific Interpretation for the Launch of New Clinical Next-Generation Sequencing Panels

Macrogen has recently partnered with N-of-One, a leader in clinical interpretation, with the goal of delivering high-level clinical interpretation for its newly launched clinical next-generation sequencing panels. N-of-One enables laboratories to save time and money while scaling their molecular diagnostics programs. It also provides therapeutic options to client organizations for thousands of cancer patient cases. With this partnership, Macrogen’s Next Generation Sequencing technology not only makes it possible to process,…

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high-throughput dna sequencing

Managing High-Throughput DNA Sequencing Data

Introduction The newest sequencing technologies are providing new insights into disease etiology, individual susceptibilities, keys to drug discovery, and more. However, there are many questions and challenges regarding how to understand the meaning and applicability of the newfound wealth of data. As new data is generated at record rates, scientists are working diligently on the development of methods to archive the massive sequencing information and create bioinformatics tools to analyze…

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Macrogen and Silicon Biosystems Menarini to Co-Develop CLIA-Certified Genomic Cancer Assays

Collaboration Aims to Integrate Digital Sorting with Next Generation Sequencing (NGS) of Formalin-Fixed Paraffin-Embedded Biopsies and Fine-Needle Aspiration Samples SAN DIEGO and SEOUL, South Korea, Feb. 12, 2016 /PRNewswire/ — Silicon Biosys­tems Menarini and Macrogen, Inc. today announced they will form a partnership to provide clinical assays and innovative procedures for precision medicine in cancer. The goal of the collaboration is to combine Silicon Biosystems’ DEPArray™ digital-sorting technology with Macrogen’s…

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