Our Blog

The Latest in Sequencing Technologies

Pancreatic Cancer

Role of Next-Generation Sequencing in Pancreatic Cancer Management

Introduction Pancreatic cancer (PC) is considered one of the most fatal cancers in the U.S. and other developed countries. The best outcomes and survival rates after treatment are only possible with early detection and treatment before the onset of symptoms. There is a great need to uncover ways to detect PC early to achieve better clinical outcomes. To date, there are no reliable means for the early, pre-symptom detection of…

Read more 2 Comments

Macrogen Microbiome

Advances in Microbiome Diagnostics

Introduction The organisms that are a part of our normal biology are essential for our survival and well-being. The genetic material of these organisms collectively makes up the human microbiome. However, there are many scientists that use the term microbiome interchangeably with microbiota (the actual normal microorganism in a particular environment, such as the human body). For the purposes of this article, microbiome will be reserved for indicating the total…

Read more One Comment

HLA-Pharmacogenetics-Macrogen-Labs

HLA and Pharmacogenetics

Introduction For years, the unpredictability of drug reactions has served as an underlying uncertainty in the safety of medications. This is because many of these reactions are specific to certain individuals and populations and under specific circumstances with an unknown basis. Adverse drug reactions can be very medically devastating, leading to severe consequences including death. The capacity to find a means to predict the risk of adverse reactions for patients…

Read more One Comment

Cloud-based Technology Concept

The Promise and Security Risks of using Cloud-Based Informatics Solutions for Human Genomic Data Analysis

Introduction The ability for medical and research scientists around the globe to share data has enhanced the progress of medical discovery and healthcare delivery. Instant access to information via cloud-based technology by researchers and healthcare providers allows more time spent acting on and processing data. However, large bodies of data (a.k.a big data) generated through new technologies such as next-generation sequencing (NGS) need special data-storage considerations. Storage of a vast…

Read more One Comment

3d rendering molecular structure. Molecules or network from glass and crystal. Abstract molecules in bright lit environment. Structural background. Molecular grid. Depth of field.

Molecular Basis of Immune Diversity and Emerging Clinical Applications

Introduction A wide variety of immune mechanisms have evolved in living organisms that serve to protect them from many types of disease-causing agents. These mechanisms differ in various ways including in how the immunity develops and how the agents or pathogens are processed and destroyed by the organism’s immune cells. These different mechanisms of defense constitute the immune diversity of species and are important for survival. A better understanding of…

Read more Leave a comment

The word "AUTISM?" spelled out in child's blocks. "Is it autism?" is a question many parents have about their kids.

Advances in Characterizing the Genetic Basis of Autism

Introduction The diagnosis of autism spectrum disorders (ASD) continues to be challenging and depends on neurological and psychological analyses. A number of risk factors and genetic associations with the disorder have been identified. However, work is ongoing to better characterize the genetic basis of ASD, to determine how to identify the risk for ASD, and to design the best therapies for those diagnosed with ASD. Given the high heritability, the…

Read more Leave a comment

Editable vector silhouettes of different stages of a woman's life

How NGS is Enabling the Ability to Counter Biological Aging

Introduction Aging has been accepted as a normal biological process that is inevitable. This deterioration of structure and function and loss of homeostasis over time is considered to some to be a collection of pathological processes or disorders that can be slowed or stopped. The search for the fountain of youth is ageless. Studies in the search for this “fountain” have begun to focus on the relationship between gene expression…

Read more Leave a comment

3d rendered, medically accurate 3d illustration of a tumor

Circulating Tumor DNA Methodologies

Introduction The analysis of cell-free DNA or liquid biopsy is emerging as a noninvasive clinical tool to aid in achieving accurate diagnoses. It is also a valuable research tool to determine biomarkers of disease, identify drug targets, and ascertain the factors responsible for drug resistance. Circulating tumor DNA refers to cell-free DNA that are fragments of DNA released from tumor cells and appearing in the blood circulation. Major challenges to…

Read more Leave a comment

Test tube with blood sample for DNA test

Home DNA vs. Clinical DNA: What’s the Difference?

Introduction Various types of home diagnostic testing or screening have placed more power and control of individual health information and care in the hands of consumers. We are well familiar with and may have used (or know someone who has) blood pressure kits, glucose measurement kits, and home pregnancy tests. Due to the next-generation sequencing (NGS) revolution, it is now possible to achieve home DNA sequencing for medical applications. However,…

Read more Leave a comment

Book with diagnosis infectious diseases. Medic concept.

Using Next-Generation Sequencing in Infectious Disease Diagnosis

Introduction The need for accurate and rapid identification of infectious agents in individual illness and global health threats cannot be overstated. Limitations in the timeliness and accuracy of pathogen identification have devastating public health consequences. The current methods that are routinely used often provide data in a time span that does not allow the most effective, specific, and direct treatment options. This leads to antibiotic treatments that are broad, based…

Read more Leave a comment