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macrogen corp accreditation

Macrogen Corp.’s Clinical NGS Laboratory Receives CAP Accreditation – Press Release

ROCKVILLE, MD – Macrogen Corp. announces that its Clinical Lab that provides clinical NGS services has been awarded accreditation by the Accreditation Committee of the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP’s Accreditation Programs. “Macrogen demonstrates leadership, innovation, and a passionate commitment to standards of excellence while providing the highest quality services, ultimately for patients,” said Bharati Jhaveri, MD,…

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Race and Predisposition to Disease

Introduction Interdisciplinary efforts over several decades have provided intriguing information regarding the factors that contribute to racial differences in health status and outcomes. Even with this information on hand, challenges remain regarding improved characterization of these various biological and environmental factors. Advances in genomic studies have provided some of the valuable tools and data needed to move forward in the direction of defining the biologic factors underlying racial differences in…

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NGS-life-expectancy

Next Generation Sequencing Could Dramatically Impact Life Expectancy

Introduction A Centers for Disease Control website provides a definition for life expectancy as “the average number of years that a hypothetical group of infants would live at each attained age if the group was subject, throughout its lifetime, to the age-specific death rates prevailing for the actual population in a given year” (1). It is essentially the time a person or other organism is expected to live based on…

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Chromatin Immunoprecipitation-sequencing (ChIP-seq)

Chromatin Immunoprecipitation assays have the ability to capture an image of specific protein to DNA interactions that are occurring in a system and process these interactions using quantitative polymerase chain reaction (qPCR), ChIP-chip, or next generation sequencing (NGS). When paired with next generation sequencing specifically, ChIP-seq is a powerful way to identify genome-wide DNA binding sites for transcription factors and other proteins. When performing ChIP-seq, chromatin is separated from cells…

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Sequencing Data to Develop Recombinant Vaccines

Introduction Eradication and prevention of infectious diseases are achieved most often via vaccination. The common or traditional vaccines are made using the actual pathogen material, such as modified live or killed (inactivated) viruses. The use of these types of vaccines is sometimes associated with serious side effects. For some infectious agents, it is often difficult to develop vaccines using this approach, and there are limitations on the effectiveness of these…

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Pancreatic Cancer

Role of Next-Generation Sequencing in Pancreatic Cancer Management

Introduction Pancreatic cancer (PC) is considered one of the most fatal cancers in the U.S. and other developed countries. The best outcomes and survival rates after treatment are only possible with early detection and treatment before the onset of symptoms. There is a great need to uncover ways to detect PC early to achieve better clinical outcomes. To date, there are no reliable means for the early, pre-symptom detection of…

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Macrogen Microbiome

Advances in Microbiome Diagnostics

Introduction The organisms that are a part of our normal biology are essential for our survival and well-being. The genetic material of these organisms collectively makes up the human microbiome. However, there are many scientists that use the term microbiome interchangeably with microbiota (the actual normal microorganism in a particular environment, such as the human body). For the purposes of this article, microbiome will be reserved for indicating the total…

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HLA and Pharmacogenetics

Introduction For years, the unpredictability of drug reactions has served as an underlying uncertainty in the safety of medications. This is because many of these reactions are specific to certain individuals and populations and under specific circumstances with an unknown basis. Adverse drug reactions can be very medically devastating, leading to severe consequences including death. The capacity to find a means to predict the risk of adverse reactions for patients…

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Cloud-based Technology Concept

The Promise and Security Risks of using Cloud-Based Informatics Solutions for Human Genomic Data Analysis

Introduction The ability for medical and research scientists around the globe to share data has enhanced the progress of medical discovery and healthcare delivery. Instant access to information via cloud-based technology by researchers and healthcare providers allows more time spent acting on and processing data. However, large bodies of data (a.k.a big data) generated through new technologies such as next-generation sequencing (NGS) need special data-storage considerations. Storage of a vast…

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Molecular Basis of Immune Diversity and Emerging Clinical Applications

Introduction A wide variety of immune mechanisms have evolved in living organisms that serve to protect them from many types of disease-causing agents. These mechanisms differ in various ways including in how the immunity develops and how the agents or pathogens are processed and destroyed by the organism’s immune cells. These different mechanisms of defense constitute the immune diversity of species and are important for survival. A better understanding of…

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